Development of epitope-based peptide vaccine against novel coronavirus 2019 (SARS-COV-2): Immunoinformatics approach.
Identifieur interne : 000225 ( Main/Exploration ); précédent : 000224; suivant : 000226Development of epitope-based peptide vaccine against novel coronavirus 2019 (SARS-COV-2): Immunoinformatics approach.
Auteurs : Manojit Bhattacharya [Corée du Sud] ; Ashish R. Sharma [Corée du Sud] ; Prasanta Patra [Inde] ; Pratik Ghosh [Inde] ; Garima Sharma [Corée du Sud] ; Bidhan C. Patra [Inde] ; Sang-Soo Lee [Corée du Sud] ; Chiranjib Chakraborty [Corée du Sud]Source :
- Journal of medical virology [ 1096-9071 ] ; 2020.
Abstract
Recently, a novel coronavirus (SARS-COV-2) emerged which is responsible for the recent outbreak in Wuhan, China. Genetically, it is closely related to SARS-CoV and MERS-CoV. The situation is getting worse and worse, therefore, there is an urgent need for designing a suitable peptide vaccine component against the SARS-COV-2. Here, we characterized spike glycoprotein to obtain immunogenic epitopes. Next, we chose 13 Major Histocompatibility Complex-(MHC) I and 3 MHC-II epitopes, having antigenic properties. These epitopes are usually linked to specific linkers to build vaccine components and molecularly dock on toll-like receptor-5 to get binding affinity. Therefore, to provide a fast immunogenic profile of these epitopes, we performed immunoinformatics analysis so that the rapid development of the vaccine might bring this disastrous situation to the end earlier.
DOI: 10.1002/jmv.25736
PubMed: 32108359
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000210
- to stream PubMed, to step Curation: 000210
- to stream PubMed, to step Checkpoint: 000229
- to stream Ncbi, to step Merge: 002560
- to stream Ncbi, to step Curation: 002560
- to stream Ncbi, to step Checkpoint: 002560
- to stream Main, to step Merge: 000228
- to stream Main, to step Curation: 000225
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Development of epitope-based peptide vaccine against novel coronavirus 2019 (SARS-COV-2): Immunoinformatics approach.</title><author><name sortKey="Bhattacharya, Manojit" sort="Bhattacharya, Manojit" uniqKey="Bhattacharya M" first="Manojit" last="Bhattacharya">Manojit Bhattacharya</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do</wicri:regionArea><wicri:noRegion>Gangwon-do</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Ashish R" sort="Sharma, Ashish R" uniqKey="Sharma A" first="Ashish R" last="Sharma">Ashish R. Sharma</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do</wicri:regionArea><wicri:noRegion>Gangwon-do</wicri:noRegion></affiliation></author><author><name sortKey="Patra, Prasanta" sort="Patra, Prasanta" uniqKey="Patra P" first="Prasanta" last="Patra">Prasanta Patra</name><affiliation wicri:level="1"><nlm:affiliation>Department of Zoology, Vidyasagar University, Midnapore, West Bengal, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Zoology, Vidyasagar University, Midnapore, West Bengal</wicri:regionArea><wicri:noRegion>West Bengal</wicri:noRegion></affiliation></author><author><name sortKey="Ghosh, Pratik" sort="Ghosh, Pratik" uniqKey="Ghosh P" first="Pratik" last="Ghosh">Pratik Ghosh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Zoology, Vidyasagar University, Midnapore, West Bengal, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Zoology, Vidyasagar University, Midnapore, West Bengal</wicri:regionArea><wicri:noRegion>West Bengal</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Garima" sort="Sharma, Garima" uniqKey="Sharma G" first="Garima" last="Sharma">Garima Sharma</name><affiliation wicri:level="1"><nlm:affiliation>Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chuncheon, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Patra, Bidhan C" sort="Patra, Bidhan C" uniqKey="Patra B" first="Bidhan C" last="Patra">Bidhan C. Patra</name><affiliation wicri:level="1"><nlm:affiliation>Department of Zoology, Vidyasagar University, Midnapore, West Bengal, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Zoology, Vidyasagar University, Midnapore, West Bengal</wicri:regionArea><wicri:noRegion>West Bengal</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Sang Soo" sort="Lee, Sang Soo" uniqKey="Lee S" first="Sang-Soo" last="Lee">Sang-Soo Lee</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do</wicri:regionArea><wicri:noRegion>Gangwon-do</wicri:noRegion></affiliation></author><author><name sortKey="Chakraborty, Chiranjib" sort="Chakraborty, Chiranjib" uniqKey="Chakraborty C" first="Chiranjib" last="Chakraborty">Chiranjib Chakraborty</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do</wicri:regionArea><wicri:noRegion>Gangwon-do</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32108359</idno><idno type="pmid">32108359</idno><idno type="doi">10.1002/jmv.25736</idno><idno type="wicri:Area/PubMed/Corpus">000210</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000210</idno><idno type="wicri:Area/PubMed/Curation">000210</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000210</idno><idno type="wicri:Area/PubMed/Checkpoint">000229</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000229</idno><idno type="wicri:Area/Ncbi/Merge">002560</idno><idno type="wicri:Area/Ncbi/Curation">002560</idno><idno type="wicri:Area/Ncbi/Checkpoint">002560</idno><idno type="wicri:Area/Main/Merge">000228</idno><idno type="wicri:Area/Main/Curation">000225</idno><idno type="wicri:Area/Main/Exploration">000225</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Development of epitope-based peptide vaccine against novel coronavirus 2019 (SARS-COV-2): Immunoinformatics approach.</title><author><name sortKey="Bhattacharya, Manojit" sort="Bhattacharya, Manojit" uniqKey="Bhattacharya M" first="Manojit" last="Bhattacharya">Manojit Bhattacharya</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do</wicri:regionArea><wicri:noRegion>Gangwon-do</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Ashish R" sort="Sharma, Ashish R" uniqKey="Sharma A" first="Ashish R" last="Sharma">Ashish R. Sharma</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do</wicri:regionArea><wicri:noRegion>Gangwon-do</wicri:noRegion></affiliation></author><author><name sortKey="Patra, Prasanta" sort="Patra, Prasanta" uniqKey="Patra P" first="Prasanta" last="Patra">Prasanta Patra</name><affiliation wicri:level="1"><nlm:affiliation>Department of Zoology, Vidyasagar University, Midnapore, West Bengal, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Zoology, Vidyasagar University, Midnapore, West Bengal</wicri:regionArea><wicri:noRegion>West Bengal</wicri:noRegion></affiliation></author><author><name sortKey="Ghosh, Pratik" sort="Ghosh, Pratik" uniqKey="Ghosh P" first="Pratik" last="Ghosh">Pratik Ghosh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Zoology, Vidyasagar University, Midnapore, West Bengal, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Zoology, Vidyasagar University, Midnapore, West Bengal</wicri:regionArea><wicri:noRegion>West Bengal</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Garima" sort="Sharma, Garima" uniqKey="Sharma G" first="Garima" last="Sharma">Garima Sharma</name><affiliation wicri:level="1"><nlm:affiliation>Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chuncheon, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Patra, Bidhan C" sort="Patra, Bidhan C" uniqKey="Patra B" first="Bidhan C" last="Patra">Bidhan C. Patra</name><affiliation wicri:level="1"><nlm:affiliation>Department of Zoology, Vidyasagar University, Midnapore, West Bengal, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Zoology, Vidyasagar University, Midnapore, West Bengal</wicri:regionArea><wicri:noRegion>West Bengal</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Sang Soo" sort="Lee, Sang Soo" uniqKey="Lee S" first="Sang-Soo" last="Lee">Sang-Soo Lee</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do</wicri:regionArea><wicri:noRegion>Gangwon-do</wicri:noRegion></affiliation></author><author><name sortKey="Chakraborty, Chiranjib" sort="Chakraborty, Chiranjib" uniqKey="Chakraborty C" first="Chiranjib" last="Chakraborty">Chiranjib Chakraborty</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do</wicri:regionArea><wicri:noRegion>Gangwon-do</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of medical virology</title><idno type="eISSN">1096-9071</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recently, a novel coronavirus (SARS-COV-2) emerged which is responsible for the recent outbreak in Wuhan, China. Genetically, it is closely related to SARS-CoV and MERS-CoV. The situation is getting worse and worse, therefore, there is an urgent need for designing a suitable peptide vaccine component against the SARS-COV-2. Here, we characterized spike glycoprotein to obtain immunogenic epitopes. Next, we chose 13 Major Histocompatibility Complex-(MHC) I and 3 MHC-II epitopes, having antigenic properties. These epitopes are usually linked to specific linkers to build vaccine components and molecularly dock on toll-like receptor-5 to get binding affinity. Therefore, to provide a fast immunogenic profile of these epitopes, we performed immunoinformatics analysis so that the rapid development of the vaccine might bring this disastrous situation to the end earlier.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li><li>Inde</li></country></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Bhattacharya, Manojit" sort="Bhattacharya, Manojit" uniqKey="Bhattacharya M" first="Manojit" last="Bhattacharya">Manojit Bhattacharya</name></noRegion><name sortKey="Chakraborty, Chiranjib" sort="Chakraborty, Chiranjib" uniqKey="Chakraborty C" first="Chiranjib" last="Chakraborty">Chiranjib Chakraborty</name><name sortKey="Lee, Sang Soo" sort="Lee, Sang Soo" uniqKey="Lee S" first="Sang-Soo" last="Lee">Sang-Soo Lee</name><name sortKey="Sharma, Ashish R" sort="Sharma, Ashish R" uniqKey="Sharma A" first="Ashish R" last="Sharma">Ashish R. Sharma</name><name sortKey="Sharma, Garima" sort="Sharma, Garima" uniqKey="Sharma G" first="Garima" last="Sharma">Garima Sharma</name></country><country name="Inde"><noRegion><name sortKey="Patra, Prasanta" sort="Patra, Prasanta" uniqKey="Patra P" first="Prasanta" last="Patra">Prasanta Patra</name></noRegion><name sortKey="Ghosh, Pratik" sort="Ghosh, Pratik" uniqKey="Ghosh P" first="Pratik" last="Ghosh">Pratik Ghosh</name><name sortKey="Patra, Bidhan C" sort="Patra, Bidhan C" uniqKey="Patra B" first="Bidhan C" last="Patra">Bidhan C. Patra</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000225 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000225 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:32108359
|texte= Development of epitope-based peptide vaccine against novel coronavirus 2019 (SARS-COV-2): Immunoinformatics approach.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32108359" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |